The Unique Nature of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10

Grant number: 1141950 | Funding period: 2019 - 2020

Completed

Abstract

The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.

Related publications (3)

Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10

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The CD8αβ heterodimer plays a crucial role in the stabilization between major histocompatibility complex class I molecules (MHC-I)..

The murine CD94/NKG2 ligand, Qa-1b, is a high-affinity, functional ligand for the CD8αα homodimer

KJ Goodall, A Nguyen, C McKenzie, SBG Eckle, LC Sullivan, DM Andrews

2020-03-06

The immune co-receptor CD8 molecule (CD8) has two subunits, CD8α and CD8β, which can assemble into homo or heterodimers. Nonclassi..

Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development

KJ Goodall, A Nguyen, A Matsumoto, JR McMullen, SB Eckle, P Bertolino, LC Sullivan, DM Andrews

2019-03-01

Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression a..

University of Melbourne Researchers

Lucy Sullivan